ESR1 and cancer: However, the ‘wound signature’, which is induced by co-ordinate amplification of MYC and CSN5/JAB1/COPS5[44], is predictive of a poor outcome in a cohort of patients with ER-positive cancers who were more commonly treated with chemotherapy than endocrine therapy [45], suggesting that deregulation of c-Myc may result in resistance to multiple therapies.