VEGFA and neoplasm: The bone marrow could also be an important component to add to the model as it is the site where pro- and anti-angiogenic factors are segregated into separate platelet α-granules to be transported within the bloodstream and possibly released at the site of the tumor [35] thus protecting VEGF from binding to receptors on the luminal side of the endothelial cells or binding to anti-VEGF agents present in the bloodstream or extravasating.