We now set the tumor VEGF165 secretion rate at 0.076 or 0.025 molecule/cell/s for 10,000 and 100,000 NRP1 in the tumor respectively, so that, at a vascular permeability in tumor of 4 × 10-8 cm/s (which corresponds to the vascular permeability of healthy tissue), the steady-state free VEGF concentration in the available interstitial fluid in the tumor corresponds to that in the available interstitial fluid in the normal tissue (~4.5 pM). This evidence concerns the gene NRP1 and neoplasm.