The list of genes with reduced expression in DA, as compared with increased expression in DA.F344(Cia5d) congenics, included seven genes that are involved in tumor suppression-like activity and cell cycle check-points, such as Aph1a, Brwd3, Gadd45b, Gmfg, Lox, and Plekhg2 (Table 3). The gene discussed is APH1A; the disease is neoplasm.