They also suggested a surveillance programme for patients with MTS or MTS-associated sebaceous gland tumours including annual clinical examination, carcinoembryonic antigen (CEA), cervical smear, chest radiography, urine cytology, colonoscopy or barium enema every 3 to 5 years, and for female patients, mammography annually or biennially to age 50 and annually thereafter, and endometrial biopsy every 3 to 5 years. This evidence concerns the gene CEACAM5 and sebaceous gland neoplasm.