One recent report found that PPARγligands 1-[(trans-methylimino-N-oxy)-6-(2-morpholinoethoxy)-3-phenyl-(1H-indene-2-carboxylicacid ethyl ester (KR-62980)] and rosiglitazone induce NSCLC apoptotic celldeath mainly through PPARγ-dependentreactive oxygen species formation via increased expression of proline oxidase,a redox enzyme expressed in mitochondria [35]. This evidence concerns the gene PPARG and non-small cell lung carcinoma.