Rosiglitazone, for example, was reported to reduce the phosphorylationof Akt, an upstream positive modulator of mTOR, and to increase PTEN, anegative modulator of mTOR, in NSCLC H1792 and H1838 cells; this resulted ininhibition of cell proliferation [42]. The gene discussed is MTOR; the disease is non-small cell lung carcinoma.