However, current evidence suggests that PPARγ ligands affect a number of mechanismsincluding regulation of the intracellular machinery involved in cell signalingand cell cycle control, inhibition of mitogenic factors and tumor promoters, preventionof tumor cell recognition of extracellular mitogenic signals, breakdown of nicotine-inducedcell survival, and modulation of the expression of angiogenic factors neededfor the development of the vascular networks that supply tumor cell (see Figure 1). Here, PPARG is linked to neoplasm.