It is important to notice that RASSF1A (Ras association (RalGDS/AF-6) domain family 1) and RARB (retinoic acid receptor, beta) mapped at 3p (3p21.3 and 3p24, respectively), SFN (stratifin, also known as 14-3-3σ) located at 1p35.3, and CDH1 (cadherin 1, type 1, E-cadherin [epithelial]) at 16q22.1, are epigenetically silenced TSGs located at loci that overlap with LOH minimal regions in human cancer. This evidence concerns the gene RASSF1 and cancer.