A comparison of these sensitivity and specificity values with those published in several studies, which evaluated the diagnostic power of CSF markers for AD (Total-tau, Phospho-tau and Abeta 1–42), reveal that p53 measurement is more sensitive (90% compared to respectively 81.4%, 81.3% and 85.9%), but less specific (77% compared to respectively 91.5%, 91.2% and 88.5%) [7]. The gene discussed is MAPT; the disease is Alzheimer disease.