TKTL1 mRNA silencing (via small interfering anti-TKTL1-mRNA constructs) leads to inhibition of cell proliferation in colorectal cancer; protein overexpression and a significant correlation to Her2 overexpression was found in breast cancer cells where 89% expressed TKTL1 and 45% showed strong expression [2,3]. The gene discussed is ERBB2; the disease is colorectal cancer.