To that end, we have systematically examined the temporal and spatial progression of human APPswe transgene expression, appearance of intracellular and extracellular Aβ1–42, human tauP301L transgene expression, appearance of pathogenic phospho-tau, and evidence of microglial activation and astrogliosis in male 3xTg-AD mice from 2 to 26 months of age. This evidence concerns the gene MAPT and Alzheimer disease.