Among these, known GK functional variants in the genes encoding the insulin degrading enzyme (IDE) [27], a G-protein receptor GPR10 [15] and an inositol -phosphatase (SHIP2) [28] are present in these congenics rats, and should have a significant impact on adiposity, hyperinsulinaemia and insulin resistance in the congenics. The gene discussed is INPPL1; the disease is Insulin resistance.