CAPN10 and type 2 diabetes mellitus: In fact, a report by Fullerton et al. [3] has shown an unusual degree of geographic structure at this locus, especially at UCSNP19 and UCSNP63 sites, suggesting positive natural selection acting either on CAPN10 gene or on closely linked locus. Despite these differences, two meta-analyses have confirmed the association of the UCSNP43 G allele with a higher risk of T2DM, whereas showed that the effect of the 112/121 haplogenotype was over-estimated in the initial studies [4], [5]