However, although Mmp13 mRNA also was strongly induced in a subpopulation of myofibroblasts in MMTV-PyMT mammary carcinomas, concurrent with early transition to invasive carcinoma, there were no effects on tumor cell proliferation, tumor growth, lung metastasis, vascularization or differentiation of the primary tumors by the absence of MMP13. The gene discussed is MMP13; the disease is invasive carcinoma.