Since its discovery, TGFBIp, has been demonstrated to have a physiologic as well as a pathologic role in other cell types including human melanoma cells, human mammary epithelial cells, human keratinocytes, human foreskin fibroblasts, and porcine articular chondrocytes following stimulation with TGF-β1 [53-56] as well as in cultures of corneal epithelial cells [57,58], primary human foreskin fibroblasts [54], human bladder smooth muscle cells [59,60], fibroblast-like synoviocytes [61], and primary HSFs [62]. This evidence concerns the gene TGFB1 and melanoma.