In contrast, stress-activated protein kinase (SAPK) and c-Jun NH2-terminal kinase (JNK) signaling, GABA receptor signaling, epidermal growth factor (EGF) signaling, interleukin-2 (IL-2) signaling, hypoxia signaling, Huntington disease signaling, cell cycle: G2/M DNA damage checkpoint regulation, and pentose phosphate pathways showed significant downregulation. Here, MAPK8 is linked to juvenile Huntington disease.