Although scleral and retinal levels of FGF-2 have been reported to be unchanged during the development of myopia or recovery from myopia in the tree shrew, the expression of the FGF-2 receptor, FGFR-1, has been shown to be upregulated in the sclera of myopic tree shrew eyes and downregulated to control eye levels during recovery, suggesting that FGF-2 plays a role in the control of scleral remodeling during visually guided ocular growth [48]. The gene discussed is FGF2; the disease is myopia.