CTSB and adenoma: Cathepsin B deficient mice had less polyps (39±2.1 adenoma of Ctsb−/− APCΔ468 mice n = 8, compared to 94±3.5 adenoma for APCΔ468 n = 16, P<0.0001 unpaired t test with Welsh correction), which had the trend to have smaller size (1.82±0.11 mm diameter for Ctsb−/− APCΔ468 mice n = 8, compared to 2.047±0.11 mm diameter for APCΔ468 n = 16, P = 0.086) (Fig. 6a).