The mean volume of the vessels stained with AngioSense 750 was 2.2 times smaller in Ctsb−/− APCΔ468 adenoma (6963±1236 μm3, Fig. 7 d&h), and 4.2 times smaller in the anti-TNFα treated APCΔ468 adenoma (3700±1444 μm3, Fig. 7 f&h), as compared to the polyps in APCΔ468 mice (15501±2144 μm3, Fig. 7 b&h). The gene discussed is TNF; the disease is adenoma.