AFP and Rare hereditary thrombophilia: Biochemical: Serum uric acid, urine dipstick (Bedside Urinalyses) 24 hour urine protein, urinary calcium excretion, hypoalbuminaemia, microalbuminuria, fibronectin, protinuria, renal and liver function tests; Ultrasound: Growth, liquor volume, Doppler (uterine, umbilical artery, Middle cerebral artery, venous, uteroplacental) Bio Physical Profile; Haematological: Anti thrombin III, platelet count, haemoglobin, fibrinogen, thrombophilia screen, Maternal serum Alpha feto protein(MSAFP), Serum Human Chorionic Gonadotropin (HCG); Computerised Tomography; Magnetic Resonance Imaging