Using their own model (based on United Kingdom Prospective Diabetes Study (UKPDS) 68 [16]), NICE concluded that human insulin analogues are the most cost-effective option and glargine was estimated to be cost-effective in Type 2 diabetes patients at increased risk of hypoglycaemia [17]; the NICE guidelines are due to be reviewed and republished in early 2009. This evidence concerns the gene INS and type 2 diabetes mellitus.