BCL2 and gastric cancer: Taken together with other data, demonstrating that spindle checkpoint compromised HCT116-MAD2+/-cells, efficiently escaped from TopoI poison-induced apoptosis [32] and that MAD2-silenced gastric cancer SGC7901 cells increased the resistance to DNA damaging agents by up-regulating Bcl-2 [33], it is reasonable to speculate that the induction of senescence and the inhibition of apoptosis might be linked to the ipo-expression of spindle checkpoint proteins and that these proteins might also modulate the sensibility to DNA damaging agents, such as TopoI inhibitors.