MYC and malignant colon neoplasm: In agreement with our evidence of MYC induction in DBTRG-05 apoptotic cells, the over-expression of MYC was already described to sensitize colon cancer cells to CPT-induced apoptosis [38] and to be necessary, in rat fibroblasts, for DNA damage-initiated apoptosis in the G2 phase of the cell cycle [39].