Further analysis of the topological architecture of the network identified three known hub cancer genes [interleukin 8 (IL8); desmin (DES) and enolase 1 (ENO1)], while two novel hub genes [RNA binding motif protein 9 (RBM9) and ribosomal protein L30 (RPL30)] may define new central elements in the gene network specific to colon cancer. This evidence concerns the gene DES and malignant colon neoplasm.