HMW HA has been shown to be protective in animal models of emphysema, can decrease the number of acute infections in chronic bronchitis in humans, can block group A streptococcus colonization in mice, can block pancreatic elastase-induced bronchoconstriction and neutrophil elastase-induced airway responses in sheep, can decrease peritoneal permeability secondary to infection in rats, and can reduce exercise-induced airway hyperreactivity in humans [19-23]. Here, ELANE is linked to chronic bronchitis.