TNF-α levels in healthy controls, active BD patients with a response to S-Ag, active BD patients without a response to S-Ag, and inactive BD patients were all elevated in response to stimulation of S-Ag peptides (p=0.001, p=0.025, p=0.033, and p=0.028, respectively; Figure 3B). This evidence concerns the gene RENBP and Behcet disease.