INSIG2 and obesity due to melanocortin 4 receptor deficiency: Potential associations of the INSIG2 rs7566605 C-allele and the PFKP rs6602024 A-allele with overweight and obesity were evaluated by performing case-control studies in the combined study sample and further in the population-based Inter99 cohort, to elucidate the effect on a population-based level, however, no association was observed (Table 1).