CD8A and infection: Proportions of cells both subpopulations fell during the first year following expression among both the overall and tetramer+ CD8 T-cells, but unlike cells expressing CD45R0, the fall continued during the second year of infection among both the HLA-D+ (p = 0.021) and HLA-D+CD45R0+ subpopulations (p = 0.008) (Fig 1C).