IMMULON plates were used to detect twogroups of sera; 30 SLE patients' sera and 60 control sera that include 15 rheumatoidarthritis, 15 polymyositis dermatomyositis, 15 sclerodema, 15 anti-Ro/anti-Lapositive sera, and 30 normal sera. The gene discussed is CALR; the disease is systemic lupus erythematosus.