IMMULON plates were used to detect threegroups of sera; 30 SLE patients' sera, secondly 60 control sera that include 15rheumatoid arthritis sera, 15 polymyositis dermatomyositis sera, 15 sclerodemasera, 15 anti-Ro/anti-La positive sera, and thirdly 30 normal sera. The gene discussed is CALR; the disease is systemic lupus erythematosus.