Mutations in Crumbs homologue 1 (CRB1; OMIM 600105) have been associated with several visual disorders including retinitis pigmentosa (RP) with [10,11] or without [11,12] preserved para-arteriolar retinal pigment epithelium, paravenous pigmented chorioretinal atrophy [13], and LCA [14,15]. This evidence concerns the gene CRB1 and Leber congenital amaurosis.