INS and diabetes mellitus: Vitreous VEGF levels were significantly higher in 12 eyes from 12 patients with the CC genotype (6061.52±5341.69 pg/ml ) compared to 59 eyes from 56 subjects with the other (CG + GG) genotypes (3026.43±2842.17 pg/ml; p<0.01); 12 PDR eyes from 12 PDR patients with the CC genotype did not differ in clinical parameters (age, diabetes duration, age of diabetes onset, lipids, blood pressure, incidence of insulin therapy, sex distribution, incidence of smoking, and incidence of panretinal photocoagulation) from 59 PDR eyes from 56 patients with the other genotypes (data not shown).