Several lines of evidence suggest that VEGF is a major stimulator of CNV in AMD, including an observed increase of VEGF in the RPE of maculae from patients with AMD [8], increase of VEGF expression in the laser model of CNV in monkey [9] and rat [10], and induction of CNV in ectopically delivered VEGF cDNA to the RPE of rats [11-13] and nonhuman primates [14]. Here, VEGFA is linked to age-related macular degeneration.