Nine genes, i.e., GUCY2D (LCA1), RPE65 (LCA2), AIPL1 (LCA4), RPGRIP1, LCA5 (LCA6), CRB1 (LCA7), CRX (LCA8), RDH12, and CEP290 (LCA10) are generally accepted to be implicated in LCA, and three additional genes (TULP1, LRAT, and IMPDH1) and two loci (LCA3 and LCA9) may also be associated with the disease (RetNet, Genetests). This evidence concerns the gene CRB1 and Leber congenital amaurosis.