In this article, we present further analyses of the 10q26 polymorphisms in a Caucasian population from the USA with advanced AMD (both geographic atrophy and choroidal neovascularization) and assess joint effects of the HTRA1rs11200638 SNP, the LOC387715/ARMS2 SNP rs10490924 (A69S), and the CFH SNP rs1061170 (Y402H). This evidence concerns the gene ARMS2 and choroidal neovascularization.