We then applied a candidate gene approach to select a final list of ten genes with the best biological potential related to asthma pathophysiology for genotyping (five in each chromosomal region): LPA, NOX3, SNX9, VIL2, VIP, ADAM8, DOCK1, FANK1, GPR123 and PTPRE (marked in bold in Table 2). This evidence concerns the gene ADAM8 and asthma.