HMGB1 has since been implicated in many other pathologies including arthritis and cancer, and many works have studied the function of extracellular HMGB1 in infectious and inflammatory disorders, its interest as a potential therapeutic target, and its role as a messenger («alarmin») when released from the nuclei of necrotic cells (for recent reviews see e.g. [6]–[10]). Here, HMGB1 is linked to Arthritis.