Midkine has been well documented to promote various activities related to oncogenesis and tumour progression, including cell migration (Takada et al, 1997), angiogenic functions (Choudhuri et al, 1997), mitogenesis (Muramatsu and Muramatsu, 1991), and antiapoptosis (Owada et al, 1999). Here, MDK is linked to neoplasm.