SLC5A5 and thyroid gland undifferentiated (anaplastic) carcinoma: The NIS promoter contains CpG islands, and a DNA demethylating agent (such as, 5-aza-2-deoxycytidine (5-Az)) combined with a histone deacetylase inhibitor has been shown to induce NIS expression and radioactive iodine uptake in follicular and anaplastic thyroid carcinoma cell lines (Venkataraman et al, 1999; Haugen, 2004).