Mutation in Dra is associated with congenital chloride diarrhea, a recessive inherited intestinal disorder characterized by watery diarrhea and severe dehydration, high levels of fecal chloride, electrolyte disturbances, including hypochloremia and hyponatremia, leading to metabolic alkalosis, hypokalemia, and death if untreated [15,23]. The gene discussed is SLC26A3; the disease is Hyponatremia.