ADIPOQ and obesity due to melanocortin 4 receptor deficiency: The existence of a relationship between high-fat diets and colorectal cancer has been speculated for a long time, but no definitive conclusions have been arrived at yet.35 It has been reported that the secretion of adiponectin from adipocytes is suppressed in obese humans.11 Considered together with the knowledge that obesity is also an important risk factor for colorectal cancer,4 we speculated that adiponectin might suppress the development of colorectal cancer.