Of the 48 cores of tumors from US Biomax BCN 962 TMA, ten cores of tumors (two cases of esophageal squamous cell carcinoma, two cases of colon adenocarcinoma, one case of breast adenocarcinoma and two cases of ovarian adenocarcinoma, one case of skin squamous cell carcinoma, one cases of pancreatic ductal adenocarcinoma, and one case of pancreatic acinar cell carcinoma) revealed positive NRIP expression. The gene discussed is DCAF6; the disease is colon adenocarcinoma.