PIGN and Zinc deficiency: No other Zap1 targets showed clear evidence for a similar combination of Zap1 induction and repression with the possible exceptions of IZH2 and PEP4. In contrast, several other genes (i.e. MCD4, UBX6, ICY2, HNT1, URA10) showed decreased expression under mild-to-moderate zinc deficiency but showed increased expression in severely zinc-limited cells.