PSAP and hyperinsulinemic hypoglycemia, familial, 4: To understand the molecular changes at the transcriptome level during the disease course of prosaposin deficiency, three mouse models were compared in this study by microarray analysis: 1) a complete deficiency [PS-/-], 2) a hypomorph [PS-NA], and 3) a hypomorph together with a GCase mutation [4L/PS-NA].