Data shown in this setting demonstrate that genes involved in TLR-mediated pathway are significantly up-regulated in intermediate or advanced lesions, including TLR1, TLR2, TLR7, and MyD88. TLR1 and TLR2 have been previously reported to be significantly regulated in atherosclerosis and their functional roles have been widely investigated in atherosclerosis [29,30]. The gene discussed is TLR1; the disease is atherosclerosis.