IL18 and acute kidney injury: Even when using a variety of additional renal outcome measures in an exploratory analysis (>25% increase in creatinine, changes in creatinine to 72 hours or 5 days, sustained increase of greater than 50%, sustained increase of greater than 25%, and a variety of the RIFLE criteria [14]) or the serum creatinine criterion defining AKI according to the network classification [15], the AUC-ROCC for IL-18 was not greater than 0.61 (Tables 3, 4, 5, 6).