BDNF and experimental autoimmune encephalomyelitis: This is relevant to MS since neurotrophic factors such as BDNF have been detected in infiltrating immune cells in CNS lesions in both experimental autoimmune encephalomyelitis (EAE) [32] and MS [33] and it has been suggested that the immune cell-mediated import of BDNF and other neurotrophic factors into the central nervous system has the functional relevance of curbing the detrimental effects of inflammation on the surrounding tissue [19].