MR-GSE tests demonstrated that genes up-regulated in the FPD-AML patients (likely to represent genes repressed by RUNX1), had an expression trend opposite to RUNX1 in the AML patients, suggesting indeed that these genes are repressed in vivo in the presence of RUNX1 (p = 7 × 10-6; Figure 2B). The gene discussed is RUNX1; the disease is acute myeloid leukemia.