Interestingly, Raut et al [31] reported that blocking COX-2 production by NS-398 in pancreatic cancer cell lines did not affect VEGF, bFGF and IL-8 production, but Singh et al [32] found that NS-398 downregulated IL-8 by 30% in a COX-2 transfected MDA-231 breast cancer cell line. Here, FGF2 is linked to familial pancreatic carcinoma.