Interestingly, Raut et al [31] reported that blocking COX-2 production by NS-398 in pancreatic cancer cell lines did not affect VEGF, bFGF and IL-8 production, but Singh et al [32] found that NS-398 downregulated IL-8 by 30% in a COX-2 transfected MDA-231 breast cancer cell line. The gene discussed is VEGFA; the disease is breast carcinoma.