ADAM2 and cancer: , such as the protein p53, which also regulates maternal reproduction [38]; the cell adhesion gene ADAM2 (P = 2.9×10−6), which is integral to fertilization [39]; and the related genes ADAM15 (P = 5.4×10−4) and ADAM29 (P = 3.4×10−4), which are strong candidates for cancer evolution driven by sexual conflict.