Although numbers of dendritic cells (CD11b−, CD11c+, Ly6G/c−, CD4− , CD8−) (Figure 2B, c) and CD4 + T (CD11b−, CD11c+, Ly6G/c−, CD8−) and CD8+ T (CD11b−, CD11c+, Ly6G/c−, CD4−) cells (Figure 2B, d and e) in all groups of infected mice increased slightly compared with numbers in PBS-inoculated animals during the course of infection, no significant differences were found between HP and LP infection groups, suggesting that these cell populations are not major contributors to the histopathological consolidation observed in lungs during HP H5N1 virus infections in mice [16]. Here, CD4 is linked to infection.