In logistic regression controlling for mother's age andthe interaction between IgM-positivity and gender we found that boys born toIgM-positive mothers showed an increased risk of developing type 1 diabetes (oddsratio [OR] 4.63; 95% confidence interval [CI] 1.22–17.6; P < .025), as compared to boys ofIgM-negative mothers. Here, CD40LG is linked to type 1 diabetes mellitus.