Ohtomo et al. wereable to show that the attenuated activity of Na+-K+-ATPaseactivity in renal tubular segments of diabetic rats is restored by C-peptide.On the other hand, an attenuation of Na+-K+-ATPaseactivity has been demonstrated to correlate with decreased erythrocytedeformability in type 1 diabetic patients [9]. This evidence concerns the gene TBK1 and type 1 diabetes mellitus.