To elucidate theintracellular mechanism by which RGZ affects adrenal cancer cell proliferation,we investigated the effects of the drug on the two main intracellular signalingpathways engaged by the activated IGF-IR, namely, the phosphatidyl inositol 3kinase (PI3K)-Akt cascade and the extracellular signal-regulated (ERK) signaling[18]. Here, AKT1 is linked to adrenal gland cancer.