In particular, ACC, as well asthe H295R cell line [6], overexpress both IGF-II [7] and its promiscuousreceptor IGF-IR [8] in comparison to adrenal adenomas and normal adrenal tissue.The overexpressed IGF-II is thought to act in a paracrine fashion through theIGF-IR to sustain tumor and cell proliferation [6, 9, 10]. The gene discussed is IGF2; the disease is neoplasm.