PPARG and colorectal cancer: Thecombination of PPARγ expression and troglitazone treatmentactivated the PRODH promoter morethan 10-fold (Figure 4).The effect could be generalized to a variety of colorectal cancer cellsand could be elicited by four different TZDs.That troglitazone induced POX through a PPARγ mediated binding to the peroxisomalproliferator response element was shown using several methods.