Theenthusiasm generated by these antitumor effects of PPARγ and the TZDs was somewhat blunted bythe finding that in C57Bl/6J-APCMin/+ mice, activation of PPARγ-mediated signaling promotes rather thaninhibits the development of colon tumors [57].APC is the tumor suppressor protein in adenomatous polyposis coli and isan integral part of the Wnt/β-catenin signaling system. Here, PPARG is linked to colonic neoplasm.