DENND2B and malaria: Immuno-epidemiological studies performed in holoendemic (Uganda) and mesoendemic (Brazil) areas have displayed a positive association between naturally acquired cytophylic IgG antibody response to the OR domain and an increased protective immunity in adults [16,17] and children [16,18], suggesting that cellular effector mechanisms, such as antibody-dependent cellular inhibition targeting the P126 protein, might play a primary role in protection against malaria.