The Chiti–Dobson equation and the many equations it inspired are robust and versatile, having successfully predicted aggregation rates of diverse disease-associated proteins [70], including amyloid β-peptide [69], tau [69], α-synuclein [69], amylin [69], lysozyme [71], etc. Moreover, increases in the predicted rates of aggregation of various mutations in amyloid β-peptide were shown to relate to increased neuronal dysfunction and degeneration in a Drosophila model of Alzheimer's disease [72]. Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.